IBIS Genetic Breast Cancer Predisposition Tool

Documentation and Download
Fairfax Radiological Consultants, P.C. provides this informational tool courtesy of the
(IBIS) International Breast Cancer Intervention Study

download IBIS Tool for Windows - v.6

  IBIS Risk Evaluator.zip
  IBIS Risk Evaluator.exe
   Example.txt

The program begins by opening the introduction screen. From this screen you can open files describing the program as well as going to the main evaluation screen. If you want to go directly to the evaluation screen the next time the program is run then you should tick the 'Start from evaluation screen' box.

The top part of the evaluation screen deals with personal information about the woman - her age at menarche, parity etc. The bottom part of the screen deals with her family history. The enclosed PowerPoint presentation gives details on some aspects of the program. The picture in the form gives the family history in the form of a pedigree diagram.

When entering details about family members if she developed breast cancer then the age at breast cancer should be put in the relevant age box, otherwise her current age should be used (or the age at which she died if applicable). If she developed ovarian cancer then a box is activated which asks for details at which age it occurred. Similarly if she developed bilateral breast cancer then a box is activated which asks for the age at which breast cancer developed in the second breast. If age is not known then '?' should be entered in the age box. If it is not known whether a relative developed breast cancer then 'u' should be typed in the age box to represent no information. If the woman has an affected niece in the family then the affected niece button should be pressed to enter the details.

The effects of weight were only assumed to affect risk once the menopause is reached. If the height is not known then the BMI cannot be calculated and so weight is ignored. The risk from height is also assumed to be independent from the BMI. If you prefer to use imperial measurements for height and weight then the imperial radio button should be clicked.

Typing '?' represents missing data. If nothing is known about parity then the unknown radio button should be pressed. Similarly if nothing is known about the woman's menopause the no information radio button should be pressed. If the woman has had atypical hyperplasia, LCIS or some other benign breast disease then the appropriate box should be ticked.

If genetic testing has taken place within the family, then the 'Genetic Testing' button can be pressed to give a form on which to enter the results. Finally to get back to the introduction screen the 'Show start up screen' button should be pressed.

For more information on this topic, please visit www.ems-trials.org/riskevaluator/.

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